评估一种用于预测中风风险的新型肥胖指标:两国农村环境中的比较队列分析
Feifei Yao1,2,3,4,5,6, Jing Cui1,2,3,4,5, Yuncheng Shen1,2,3,4,5
1Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Baojian Road 157, Harbin, Heilongjiang Province, 150081, People's Republic of China.
BMC public health
|November 28, 2024
概括
中国农村居民因内脏肥胖而面临更高的中风风险,多病症起着关键的调解作用. 三甘油-葡萄糖-身体圆度指数 (TyG-BRI) 显示出预测这些人群中缺血性中风的前景.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢综合征研究 代谢综合征研究
- 公共卫生研究 公共卫生研究
背景情况:
- 有限的研究将脂肪分布指数 (例如,身体圆度指数 (BRI)) 与甘油三糖指数 (TyG) 结合起来,用于评估中风风险.
- 不同地区对肥胖指标和中风发病率的比较研究很少.
研究的目的:
- 调查肥胖相关参数 (包括TyG指数和复合指数) 与中风发病率之间的关联.
- 检查多病症在肥胖指标和中风之间的关系中的调解作用.
- 为了比较这些协会在中国和英国的农村人口.
主要方法:
- 一项对来自中国和英国的60,685名参与者的队列研究.
- 计算肥胖指标 (TyG指数,BMI,腰围 - WC,脂肪质量指数 - FMI,BRI,RBI) 和复合TyG指数.
- 对中风风险的考克斯回归分析和对多重疾病影响的多重调解分析.
主要成果:
- 中国居民的内脏肥胖 (BRI) 和多发病率较高,中风发病率高于英国居民.
- 与TyG指数相关的参数与缺血性中风相关,在调整多发病率后,相关性会减少.
- 多发病率调解了TyG指数和缺血性中风之间的关系,中国的调解百分比高 (高达51%) 比英国 (高达27.2%).
- TyG-BRI在中国农村居民的缺血性中风中表现出强大的预测性能.
结论:
- 在中国农村居民中,较高的内脏肥胖症有助于中风易感,并受到多病症的显著介导.
- 综合性多病症的综合管理对于有效的中风预防策略至关重要.
- 泰格-BRI成为农村社区环境中缺血性中风发病率的潜在预测因素.
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