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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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用于生物医学应用的植物性材料.

Lele Li1,2,3, Danni Zhong1,2,3, Shoujie Wang1

  • 1Department of Plastic Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, 322000, Yiwu, China. zhoum@zju.edu.cn.

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概括

植物生物材料为各种生物医学用途提供生物相容和生物降解的解决方案,包括组织工程和药物输送. 需要进一步的研究来规范它们的隔离和临床翻译.

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 纳米技术纳米技术

背景情况:

  • 植物性材料具有固有的生物相容性和生物降解性,使其成为生物医学应用中的有希望的替代品.
  • 现有的研究突出了各种植物性材料,如多糖,蛋白质和生物质,用于治疗.
  • 这些材料比传统来源具有优势,包括减少污染风险和道德问题.

研究的目的:

  • 为生物医学应用提供流行植物衍生材料的简要概述.
  • 突出这些材料的加工技术和形式 (纳米粒子,纳米纤维,水凝).
  • 强调在医学中使用植物性材料的优势和挑战.

主要方法:

  • 关于普遍存在的植物性材料的文献综述.
  • 根据成分对材料进行分类 (多糖,蛋白质等). ) 的情况.
  • 分析加工技术和由此产生的材料形式.
  • 评估在伤口愈合,组织工程和药物输送中的应用.

主要成果:

  • 确定了主要的植物衍生材料:基于多糖的聚合物,基于蛋白质的聚合物,细胞外囊泡,粘液,脱细胞化的支架和整个植物生物质.
  • 在材料形式中展示了多功能性:纳米粒子,纳米纤维和水凝.
  • 突出的好处:低内毒素/病毒风险,道德优势,可扩展性和环保性.
  • 已知在伤口愈合,组织工程和药物输送中的应用.

结论:

  • 由于其有利的特性,植物衍生材料对生物医学应用具有重大潜力.
  • 标准化隔离方法和进展到临床试验是关键的下一步.
  • 这些生物材料为先进的医学疗法提供了可持续和安全的替代方案.