[患有阻塞性睡眠呼吸暂停的儿童喉微生物学的特征]
1Department of Emergency,Nanjing First Hospital,Nanjing Medical University,Nanjing,210028,China.
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的儿童表现出喉微生物组的改变,微生物丰富度降低,组成受损. 这一发现为OSA病原体和潜在的治疗点提供了新的见解.
科学领域:
- 微生物学 微生物学
- 儿科肺病学 儿科肺病学
- 基因组学就是基因组学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的儿童疾病.
- 儿科OSA的发病因子尚未完全理解.
- 微生物组的改变与各种疾病有关.
研究的目的:
- 为了研究患有OSA的儿童的喉微生物群.
- 探索微生物学在OSA病原发生中的作用.
- 为OSA预防,诊断和治疗提供新的见解.
主要方法:
- 招募了20名患有OSA的儿童和20名健康的对照.
- 用于微生物组分析,收集了喉拭子.
- 使用16S rRNA基因测序来表征微生物组.
主要成果:
- 在OSA组中增加了α多样性 (Chao1,观察到的OTU).
- 在OSA和对照组之间,β多样性的显著差异.
- 在OSA患者中增加了Hemophilus (蛋白质细菌) 的丰度,减少了Veillonella (Firmicutes) 和Prevotella (Bacteroidota) 的丰度.
结论:
- 儿科OSA与喉微生物丰富度的降低有关.
- 在患有OSA的儿童中,喉微生物组的组成发生显著的破坏.
- 微生物组分析为小儿OSA病原发生提供了新的视角.
更多相关视频
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
19.7K
04:32Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
11.7K
相关概念视频
Chronic Pharyngitis
1.2K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
1.2K
Tonsillitis I: Introduction
208
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
208
Sleep Apnea
128
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
128
Acute Pharyngitis
441
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
441
Pneumonia I: Introduction
211
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
211
Suctioning the Oropharyngeal Airway
179
In preparing for oropharyngeal airway suctioning, a nurse must gather all necessary equipment, including a suction unit with tubing, a prepackaged suction kit, sterile gloves, water or saline for irrigation, a water-soluble lubricant, and additional personal protective equipment (such as a gown, mask, and goggles) to control infections.
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
179
