对脑干和基底前脑中兴奋和自主中心的多模态状态依赖连接性分析
Haatef Pourmotabbed1,2,3, Caroline G Martin2,3,4, Sarah E Goodale1,2,3
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
bioRxiv : the preprint server for biology
|November 28, 2024
概括
大脑兴奋中心通过警觉动态地改变它们的网络连接. 这项研究揭示了脑干和基础前脑核在警觉变化期间如何转移连接,从而影响认知.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 脑部成像 脑部成像
背景情况:
- 警觉,一个动态的皮层激活状态,影响认知和行为.
- 大脑干和基底前脑中的神经调节核调节兴奋,但它们的网络变化与警是不太了解的.
研究的目的:
- 调查大脑干和基本前脑兴奋中心的警觉依赖功能连接.
- 为了阐明大脑大规模网络架构如何在警觉和昏昏欲睡之间发生变化.
主要方法:
- 同时的脑电图 (EEG) 和3T多回声功能磁共振成像 (fMRI).
- 在低警状态和高警状态期间分析连接模式.
- 使用人类连接组项目 3T 和 7T fMRI 数据集进行验证.
主要成果:
- 在低警觉期间,兴奋核显示出更强的全球相关性和与大理子,前皮质和感觉/运动皮质的连接性.
- 在警觉状态下,这些核最强烈地与突出,默认模式和听觉网络相连.
- 警觉依赖的连接模式可以在不同的fMRI模式 (3T多回声,3T单回声,7T单回声) 中重现.
结论:
- 神经调节系统表现出动态的,依赖于警的连接性概况.
- 这些发现为在不同意识状态的脑网络功能中兴奋中心的作用提供了新的见解.
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