相关实验视频

Updated: Jun 6, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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改变GPCR G蛋白亚型选择性的全调节器的设计

Madelyn N Moore1, Kelsey L Person1, Abigail Alwin1

  • 1Department of Pharmacology, University of Minnesota Twin Cities, Minneapolis, MN, USA.

bioRxiv : the preprint server for biology
|November 28, 2024
PubMed
概括

研究人员通过准受体-传感器接口来设计有偏见的GPCR调节器. 对SBI-553微调的G蛋白亚型对NTSR1的选择性进行了微小的化学修改,从而实现了合理的药物发现.

关键词:
选择性G蛋白的选择性G蛋白结合受体的受体是G蛋白结合受体的受体.通过全osteric 调制.有偏见的信号传输.神经素受体 1 个这是一种β-arrestin.

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