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Updated: Jun 6, 2025

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
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基于HSPC的抗HIV-1基因疗法使用安全杀死开关来防御和攻击HIV-1感染

Qi Guo1,2,3, Keval Parikh1,2, Jian Zhang1,2

  • 1UCLA AIDS Institute, UCLA, Los Angeles, CA, USA, 90024.

bioRxiv : the preprint server for biology
|November 28, 2024
PubMed
概括

造血干细胞基因疗法在HIV-1缓解方面表现有前途. 一个新的载体共同表达了三种抗HIV基因和一个安全开关,显著降低了小鼠的病毒载量.

关键词:
在C46膜中定HIV-1融合抑制剂.在CCR5短毛线RNARNA中.基于CD4的抗HIV-1化学抗原受体.在体内通过 cetuximab 介导的负选择.艾滋病病毒-1 艾滋病病毒-1基于血造干细胞/原始细胞 (HSPC) 的基因疗法.人性化的小鼠.截断的人类EGFR (huEGFRt)

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