在六种模型多细胞真核生物中,随着基因年龄的增长,性变异性增加
Reese Martin1,2, Ann T Tate1,2
1Department of Biological Sciences, Vanderbilt University, Nashville TN, 37235.
bioRxiv : the preprint server for biology
|November 28, 2024
概括
基因年龄会影响类型,其中单个基因会影响多个特征. 中年和古老的基因在不同物种中显示出比年轻的基因更高的质,这表明基因年龄和功能进化之间存在着根本的关系.
科学领域:
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
- 基因组学就是基因组学.
背景情况:
- 基因功能和长度等基因特征因基因年龄而异.
- 单个基因影响多个特征的类型是由诸如选择和亚功能化之类的进化力量塑造的.
- 随着时间的推移,这些力量与类型的流行之间的动态相互作用仍然不清楚.
研究的目的:
- 为了研究基因年龄和多细胞真核生物多种多细胞真核生物之间的关系.
- 为了测试这个假设,类型变性患病率随着基因年龄的预测而变化,可能在中年基因中达到顶峰.
主要方法:
- 通过使用Open Tree of Life和OMAdb.com识别远距离相关物种的基因年龄来计算基因年龄.
- 通过蛋白质-蛋白质相互作用 (STRINGdb) 和基因本体学 (GO) 生物过程评估类状况.
- 分析了来自模型生物的数据,包括人类,小鼠,斑马鱼,果,线虫和.
主要成果:
- 与年轻基因相比,中年和古老的基因表现出明显更高的质.
- 这种年龄依赖的类型在所有研究的物种和两种测量方法 (蛋白质相互作用和生物过程) 中都是一致的.
- 根据基因功能类也观察到类的差异,特别是在检查生物过程计数时.
结论:
- 基因年龄和类型之间存在着根本的关系.
- 对这种关系的进一步研究可以阐明推动基因在进化时间内的功能变化的机制.
- 基因年龄是理解基因的功能复杂性和进化轨迹的关键因素.
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