副腹腔和上视野下垂体核中的催产素神经元双向调节食物摄入量
Jessica J Rea1,2, Clarissa M Liu1,2, Anna M R Hayes1
1Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA.
bioRxiv : the preprint server for biology
|November 28, 2024
概括
副腹腔核 (PVH) 中的催产素神经元减少食物摄入量,而超视核 (SON) 中的催产素神经元增加食物摄入量. 这些在控制食欲方面的独特作用突出了不同的和信号.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为科学 行为科学
背景情况:
- 催产素 (OT) 是一种已知影响食物摄入的下丘脑神经.
- 之前使用一般OT给药的研究表明食物摄入量减少,但没有区分特定的下丘脑核的作用.
研究的目的:
- 研究催产素 (OT) 神经元在下丘脑的副腹腔核 (PVH) 和上视核 (SON) 中在调节食物摄入中的不同作用.
- 为了区分PVH与PVH的影响. 控制食欲的SON OT神经元活动.
主要方法:
- 利用专门由设计药物 (DREADDs) 激活的设计受体来选择性地激活大鼠PVH或SON中的OT神经元.
- 采用病毒介导的方法来使PVH或SON OT神经元的突触传输沉默.
- 在针对性神经元操纵后,监测食物消耗 (,高脂肪高糖饮食,液糖) 和食大小.
主要成果:
- 激活PVH OT神经元通过减少食大小,降低了食和高脂肪高糖饮食的消费.
- 激活SON OT神经元增加了和液糖的摄入量,而摄入量的增加是由更大的食大小介导的.
- 沉默PVH OT神经元通过更大的食物大小增加了高脂肪高糖饮食消费.
- 沉默SON OT神经元通过减少食大小来减少食消费.
结论:
- 在PVH和SON中的催产素神经元对食物摄入产生相反的,核特异性的控制.
- PVH OT神经元似乎促进了和,而SON OT神经元可能会减少和信号.
- 这些发现揭示了下丘脑中不同OT神经元群体对食欲的差异调节.
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