Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomics02:02

Genomics

35.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.9K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

T-cell repertoire response in individuals with post-acute sequelae of COVID-19.

bioRxiv : the preprint server for biology·2026
Same author

KGBN: Augmenting and optimizing logical gene regulatory networks using knowledge graphs.

bioRxiv : the preprint server for biology·2026
Same author

Drivers of clinical resistance to venetoclax and hypomethylating agents in acute myeloid leukemia and strategies for improving efficacy.

HemaSphere·2026
Same author

LinkML: an open data modeling framework.

GigaScience·2025
Same author

Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation.

bioRxiv : the preprint server for biology·2025
Same author

Prognostic impact of age and MDS-associated mutations in <i>NPM1</i> -mutated AML.

medRxiv : the preprint server for health sciences·2025
Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026
Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026
Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026
Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026
Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026
Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 6, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.6K

从知识库,注册表和多原子数据中生成生物医学知识图.

Guangrong Qin1, Kamileh Narsinh1, Qi Wei1

  • 1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.

bioRxiv : the preprint server for biology
|November 28, 2024
PubMed
概括
此摘要是机器生成的。

这项研究将大型临床和多经济学数据集转化为可计算的知识图 (KG),用于自动推理. 由此产生的KG增强了生物医学研究,同时保护了患者的隐私.

关键词:
欧洲人权理事会 欧洲人权理事会生物医学翻译 生物医学翻译临床数据 临床数据数据科学数据科学数据转化为知识.电子健康记录是电子健康记录.知识的知识知识的知识.知识图表知识图表多种多种多种多种多种多种多种多种多种多种.

更多相关视频

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

17.5K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

8.9K

相关实验视频

Last Updated: Jun 6, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.6K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

17.5K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

8.9K

科学领域:

  • 生物医学信息学 生物医学信息学
  • 数据科学数据科学数据科学
  • 知识表示 知识表示

背景情况:

  • 大规模的临床和多经济学数据集正在增长,需要转化为可用于自动推理的可操作信息.
  • 数据可访问性的障碍包括内容多样性,大小和隐私问题,阻碍有效的数据利用.
  • 现有系统需要协调目标,标准和资源,以实现可靠的数据转换.

研究的目的:

  • 在知识图 (KG) 结构中将多态数据集和电子健康记录 (EHR) 转换为紧的知识表示.
  • 为了在生物医学数据翻译器生态系统中展示这种数据转换.
  • 提供访问五个由此产生的KG,并展示它们在回答生物医学研究问题的实用性.

主要方法:

  • 利用知识图 (KG) 进行结构化,机器学习可读的知识表示.
  • 开发用于将多学科数据和EHR转换为KG数据结构的方法.
  • 将转换的数据集成到生物医学数据翻译器框架中,确保隐私保护.

主要成果:

  • 成功地将各种数据集 (临床试验,药物批准,癌症,健康,电子健康记录) 转化为五个不同的KG.
  • 在数据转换过程中证明了个人隐私的保护.
  • 通过翻译框架提供访问生成的KG.

结论:

  • 开发的方法可以将复杂的生物医学数据转化为可计算的KG,支持自动推理.
  • 通过使数据更容易获得和可操作,同时保持隐私,KG方法促进了生物医学研究.
  • 需要进一步的研究来应对从多组数据中提取生物医学知识的挑战.