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Updated: Jun 6, 2025

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基于合规组合的框架使拉萨病毒候选疫苗的快速开发成为可能

Nitesh Mishra1, Gabriel Avillion1, Sean Callaghan1

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037 USA.

bioRxiv : the preprint server for biology
|November 28, 2024
PubMed
概括

人工智能稳定了拉萨病毒葡萄糖蛋白复合体 (GPC),这是疫苗的关键目标. 这种人工智能驱动的方法增强了蛋白质的稳定性和表达,为改进的拉萨病毒疫苗开发铺平了道路.

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相关概念视频

Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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