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Updated: Jun 6, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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由雄激素受体交换活化域和小分子药物形成的共价添加物仍然是无序的

Jiaqi Zhu1, Paul J Robustelli1

  • 1Department of Chemistry, Dartmouth College, Hanover, NH, USA.

bioRxiv : the preprint server for biology
|November 28, 2024
PubMed
概括

向雄激素受体交换活化域的小分子形成共价添加物,改变蛋白质结构. 分子动力学模拟显示,这些附加物稳定了崩的螺旋形状,有助于开发前列腺癌的强效抑制剂.

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