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Updated: Jun 6, 2025

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癌症相关突变对多 (ADP-ribose) 聚合酶1抑制的影响

Neel Shanmugam1, Shubham Chatterjee2, G Andrés Cisneros2,3

  • 1Department of Chemistry, University of North Texas, Denton, TX 76201, USA.

bioRxiv : the preprint server for biology
|November 28, 2024
PubMed
概括

在V762A变体的Poly (ADP-ribose) 聚合酶1 (PARP1) 结合FDA批准的抑制剂,如talazoparib更有效地. 这种PARP1变体和抑制剂相互作用会影响DNA修复动态和癌细胞亡.

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