骨形态遗传蛋白信号通路 - 乙醇相互作用破坏了独立于gata3的口腔形成
bioRxiv : the preprint server for biology
|November 28, 2024
概括
乙醇暴露导致胎儿酒精谱系障碍 (FASD) 通过破坏Bmp信号,影响的发展独立于gata3基因. 斑马鱼模型揭示了Bmp突变物影响表皮发育的早期乙醇敏感性.
科学领域:
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
- 毒理学 毒理学 毒理学
背景情况:
- 胎儿酒精谱系障碍 (FASD) 与乙醇的致病性有关,有越来越多的证据表明基因的贡献.
- 遗传倾向可能会解释FASD变异性以及乙醇剂量和时间.
- 了解基因-乙醇相互作用对于破译FASD机制至关重要.
研究的目的:
- 调查Bmp信号在乙醇诱导的面缺陷中的作用.
- 确定涉及乙醇敏感性和FASD的特定基因.
- 为了阐明Bmp信号传递,gata3和在口腔发育中的乙醇暴露之间的时间关系.
主要方法:
- 利用斑马鱼作为一个模型生物来选基因-乙醇相互作用.
- 为乙醇敏感性和 palatal 缺陷生成和分析了 Bmp 途径突变.
- 评估基因表达模式 (gata3) 和发育时间响应乙醇和Bmp信号调制.
主要成果:
- Bmp路径突变体表现出乙醇敏感性,导致斑马鱼的 palatal 缺陷.
- 乙醇干扰了Bmp-依赖的口腔发育,独立于gata3.
- 在Bmp突变体中,乙醇敏感性发生在早期 (10-18 hpf),在gata3调节之前,这表明上皮细胞发育受到干扰.
结论:
- 乙醇通过独立于和早于gata3的作用的机制扰乱了Bmp-依赖的口腔发育.
- 早期接触乙醇会通过Bmp信号影响上皮质形态发生.
- 斑马鱼是研究与FASD相关的基因-乙醇相互作用的有价值模型.
相关概念视频
03:14Notch Signaling Pathway
4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
02:33Hedgehog Signaling Pathway
7.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.3K
01:41Non-Canonical Wnt Signaling Pathways
7.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.2K
02:30Genomic Imprinting and Inheritance
33.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.3K