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Updated: Jun 6, 2025

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
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Published on: August 13, 2012

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特里卡夫塔通过收紧特定的酸化依赖的域间相互作用来拯救F508del-CFTR

Guangyu Wang

    bioRxiv : the preprint server for biology
    |November 28, 2024
    PubMed
    概括

    特里卡夫塔通过异质稳定NBD1域来纠正囊性纤维化缺陷. 这种药物治疗通过逆转由F508del突变引起的热和门缺陷来增强通道功能.

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