长黄的保护作用对由乙胺诱导的男性不孕症
Fatima S Alaryani1, Fatima A Jaber1, Boudor S Almutiri1
1Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Journal of advanced veterinary and animal research
|November 28, 2024
概括
黄 (Curcuma longa (Cl)) 通过作为抗氧化剂的作用减轻了小鼠中酸胺 (TAA) 诱导的丸毒性. 这项研究证明了Cl在保护丸结构和功能免受TAA损伤方面的潜力.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 生殖生物学 生殖生物学
背景情况:
- 已知硫乙胺 (TAA) 诱导丸损伤.
- 氧化应激在TAA诱导的丸毒性中起着重要作用.
- 长 (Curcuma longa) (Cl) 具有抗氧化性质. 长具有抗氧化性质.
研究的目的:
- 研究TAA对大鼠丸结构和功能的毒性影响.
- 评估Curcuma longa (Cl) 对TAA诱导的丸毒性的治疗疗效.
- 评估Cl对TAA治疗大鼠的氧化应激标志物和荷尔蒙水平的影响.
主要方法:
- 雄性白色大鼠被分为四组:对照组,只有Cl,只有TAA和Cl + TAA.
- TAA是通过腹膜内注射的,而Cl是通过口服的.
- 身体和丸的体重,荷尔蒙水平 (LH,FSH,) 和氧化应激标志物 (MDA,GSH) 在8周后被分析.
主要成果:
- TAA治疗显著降低了身体和丸的重量,以及 (T) 和谷氨 (GSH) 的水平.
- TAA显著增加了黄素化激素 (LH),卵泡刺激激素 (FSH) 和甲 (MDA) 的水平.
- 长黄 (Cl) 的使用逆转了这些TAA诱导的变化,降低了LH,FSH和MDA,同时增加了T和GSH.
结论:
- 长 (Cl) 在减轻TAA诱导的丸损伤方面表现出治疗作用.
- 作为抗氧化剂,减少氧化应激,恢复荷尔蒙平衡.
- 需要进一步的研究来阐明丸毒性的Cl的机制和临床应用.
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