前列腺癌:在坦桑尼亚接受查的非洲男性中,前列腺特异抗原的负担和相关性
Bartholomeo Nicholaus Ngowi1,2,3, Alex Mremi1,4, Mshangama Juma Seif2
1Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Research and reports in urology
|November 28, 2024
概括
血清前列腺特异性抗原 (PSA) 有效预测40岁以上坦桑尼亚男性的前列腺癌 (PCa). 较高的PSA水平与PCa和侵袭性疾病有很强的相关性,这表明它对查的临床有用性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 前列腺特异性抗原 (PSA) 是前列腺癌 (PCa) 查的关键生物标志物.
- 种族差异可能会影响PSA水平和PCa之间的相关性.
- 调查PSA在PCa诊断中的作用对于坦桑尼亚人来说至关重要.
研究的目的:
- 评估坦桑尼亚男性血清PSA水平和PCa诊断之间的相关性.
- 为了确定PSA对PCa和侵袭性疾病的预测值.
- 评估坦桑尼亚社区中PCa的负担.
主要方法:
- 在坦桑尼亚北部进行社区查 (2022年5月至9月).
- 包括40岁及以上的男性.
- 血清PSA测量,前列腺活检PSA>4 ng/mL,以及独立的病理评估.
- 使用STATA版本17.0.0进行统计分析.
主要成果:
- 6164名非洲男性参与;14.8%的PSA>4 ng/mL,30.8%被诊断为PCa.
- 在PSA水平和PCa/侵袭性疾病之间观察到强烈的正相关性.
- PSA 显示出 84% 的总体预测 PCa 的能力,最佳切线>10 ng/mL.
结论:
- 在研究社区中发现了中高等级PCa的显著流行率.
- 建议定期对PCa进行查和管理策略.
- PSA 是一个临床上有用的工具,用于预测40岁及以上的非洲男性的PCa.
更多相关视频
07:34Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
Published on: November 17, 2023
613
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.0K
相关概念视频
01:20Disorders of the Male Reproductive System
331
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
331
03:03mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328