大脑年龄差距,痴呆症风险因素和中年人的认知能力
James D Stefaniak1,2, Elijah Mak1, Li Su1,3
1Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SP, UK.
Brain communications
|November 28, 2024
概括
中年成年人的大脑年龄差距与可修改的痴呆症风险因素,如高血压和酒精摄入量有关. 这一发现为未来的痴呆症预防疗法提供了潜在的目标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 大脑年龄差距,即时间和预测大脑年龄之间的差异,与老年人痴呆症有关.
- 它与痴呆症风险因素和中年认知功能的关联仍然不太了解.
研究的目的:
- 研究大脑年龄差距与痴呆风险因素,遗传倾向和中年队列认知表现之间的关系.
- 探索中年大脑年龄差距对痴呆症预防的影响.
主要方法:
- 利用T1加权的3TMRI扫描来预测PREVENT-Dementia研究中的552名认知健康的中年参与者的大脑年龄.
- 使用COGNITO计算机化测试电池评估认知能力,并收集了高血压,酒精摄入量,阿波利波蛋白E epsilon 4等位基因和粉样蛋白PET的数据.
- 采用统计分析来确定大脑年龄差距与各种因素之间的关联.
主要成果:
- 在大脑年龄差距和高血压 (P = 0.007) 和较高的酒精摄入量 (P = 0.008) 之间发现了显著的关联.
- 没有观察到大脑年龄差异和阿波利波蛋白E epsilon 4等位基因 (P = 0.14),粉样蛋白沉积 (P = 0.39) 或认知表现 (P = 0.74) 之间存在显著的关联.
结论:
- 中年人的大脑年龄差距与可修改的痴呆风险因素有关.
- 这些发现表明,针对可修改的风险因素的干预措施可能对中年人群中痴呆症预防策略至关重要.
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