产前相关的早产和潜在的预防药物的表观遗传生物标志物
Eric E Nilsson1, Paul Winchester2, Cathy Proctor2
1Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, United States.
Environmental epigenetics
|November 28, 2024
概括
研究人员在母亲口腔细胞中发现了389个DNA甲基化差异,这些差异可能预测出产前引起的早产 (PTB). 这种表观遗传生物标志物显示出早期检测和预防策略的潜力,在初步验证中达到78%的准确性.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 孕产妇健康 孕产妇健康
- 生物标志物发现发现
背景情况:
- 过早分娩 (PTB) 影响超过10%的出生,孕前是主要的亚型.
- 目前的临床方法缺乏可靠的生物标志物来预测产前引起的PTB.
- 表观遗传变化,特别是DNA甲基化,被探索为潜在的预测标记.
研究的目的:
- 调查母体口腔细胞中的DNA甲基化差异,作为预先怀孕诱导PTB的潜在生物标志物.
- 为了确定与先兆子相关的特定差异性DNA甲基化区域 (DMRs).
- 评估这些DMR作为预测生物标志物的初步准确性.
主要方法:
- 在非孕前症的产期婴儿与孕前症PTBs的母体口腔细胞中的DNA甲基化模式的比较.
- 全基因组分析以确定差异性DNA甲基化区域 (DMR).
- 交叉验证分析用于初步准确性评估.
主要成果:
- 鉴定了389种与子宫前相关的全基因组DMR,主要是在CpG密度较低的区域.
- 发现与之前识别的PTB口腔细胞表观遗传生物标志物有15%的重叠,突出了先兆子的独特DMR.
- DMRs与PI3K-Akt信号通路和代谢基因家族有关,包括脂信号.
- 通过初步验证,DMRs作为预测生物标志物的准确率达到78%.
结论:
- 这项研究提供了使用母体口腔细胞对产前激发PTB的表观遗传生物标志物的概念证明.
- 已识别的DMR为早期检测和临床治疗妊娠前提供了潜在的潜力.
- 需要在怀孕早期进行进一步的临床试验来验证这些发现,并使预防医学方法成为可能.
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