食物中毒后的肝衰竭,一个未被认可的实体:一个病例报告
Olivier Chatelanat1, Mikaël de Lorenzi-Tognon2, Laurent Spahr3
1Department of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva 1205, Switzerland. olivier.chatelanat@gmail.com.
World journal of hepatology
|November 28, 2024
概括
细菌类食物中毒可以导致严重的肝衰竭在成年人,不仅仅是儿童. 早期使用N-乙半氨酸治疗可能有助于预防这种罕见但严重的疾病导致的肝损伤.
科学领域:
- 医学微生物学 医学微生物学
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 细菌花 (B. cereus) 引起腹和吐性食物传播疾病,但往往没有得到充分报道.
- 严重的结局,如肝衰竭是罕见的,但有记录,主要是在儿科和年轻成人群体.
- 这一案例突出了与B. cereus食物中毒相关的成年肝衰竭.
研究的目的:
- 报告一名成年人由于B. cereus食物中毒而出现严重肝衰竭的罕见病例.
- 讨论cereulide毒素在肝功能障碍中的潜在作用.
- 建议对B. cereus引起的肝损伤进行治疗考虑.
主要方法:
- 一个48岁的女性呈现食物中毒症状的案例研究.
- 临床评估,包括实验室检测肝功能,凝血和狂肠溶解.
- 对患者便样本和可疑的食物来源 (大米沙拉) 的微生物学分析.
- 用N-乙システ因治疗和支持性护理.
主要成果:
- 患者在食用大米沙拉后出现了急性肝功能障碍,代谢性酸症,高乳糖血症和狂肠分裂.
- 在便样本和大米沙拉中发现了B. cereus;其他导致肝衰竭的原因被排除在外.
- 肝功能参数和临床状况在支持性护理和N-乙半氨酸治疗后得到改善.
- 在逐渐改善之前,Rhabdomyolysis最初恶化.
结论:
- 这一案例证明了B. cereus食物中毒的罕见实例,在成年人中引起显著的肝细胞功能障碍.
- 由于潜在的肝毒性,在怀疑食物中毒时应谨慎使用或避免使用乙氨基.
- 通过抵消氧化应激,N-乙半氨酸可能是一种有益的疗法,可以减轻肝细胞亡.
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