基因预测的吸烟和体重指数调解了失眠和心肌梗塞之间的关系
Limei Deng1, Yuan Gao2, Dongmei Wan1
1The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Frontiers in cardiovascular medicine
|November 28, 2024
概括
失眠显著增加了心肌梗塞 (MI) 的风险. 吸烟开始和更高的体重指数 (BMI) 调解了这种风险,这表明生活方式的改变可能有助于减轻风险.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传流行病学遗传流行病学
- 睡眠医学 睡眠医学
背景情况:
- 失眠是一种普遍的睡眠障碍,可能与心血管疾病有关.
- 了解失眠和心肌梗塞 (MI) 之间的因果关系对于公共健康至关重要.
- 以前的研究表明,生活方式因素可能会调解失眠和心脏病发作之间的关系.
研究的目的:
- 调查失眠和心肌梗塞风险之间的因果关系.
- 探索吸烟开始,酒精消费和身体质量指数 (BMI) 在这种关系中的调解作用.
- 使用孟德尔随机化 (MR) 分析来进行强有力的因果推断.
主要方法:
- 采用孟德尔的随机化 (MR) 分析,使用来自超过120万欧洲祖先的个体的遗传数据.
- 利用大规模的全基因组关联研究 (GWAS) 对与失眠,心脏病发作,吸烟开始,酒精消费和BMI相关的遗传仪器.
- 应用单变量和多变量MR分析来评估直接和间接的影响.
主要成果:
- 在失眠和心脏病发作风险增加之间发现了显著的因果关系 (OR=1.96,95% CI:1.67-2.31).
- 吸烟开始和BMI被确定为显著的调解因素,分别解释了29%和15%的总影响.
- 吸烟开始和BMI的联合调解占失眠-MI风险的54%.
结论:
- 失眠是心肌梗塞的因果风险因素之一.
- 针对戒烟和体重管理的干预措施可能会降低失眠患者的心脏病发作风险.
- 需要进一步的研究来确定其他可修改的调解者,这些调解者有助于失眠-MI路径.
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