在子宫内暴露于和多醇基物质 (PFAS) 与人类婴儿T辅助细胞发育的改变有关
medRxiv : the preprint server for health sciences
|November 28, 2024
概括
产前暴露在per-和多基基物质 (PFAS) 中会影响婴儿T细胞免疫力. 母亲的PFAS水平与12个月大时改变的CD4+T细胞亚群,特别是T囊辅助细胞和T辅助2细胞有关.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 发展性毒理学 发展性毒理学
背景情况:
- 产前接触有毒化学物质可能会破坏婴儿的发育和免疫功能.
- 和多醇基物质 (PFAS) 与成人和儿童的免疫毒性有关.
- 发育期PFAS暴露对婴儿T细胞免疫力的影响仍然在很大程度上未被描述.
研究的目的:
- 模拟婴儿CD4+T细胞亚群的纵向变化,从出生到12个月.
- 调查子宫内PFAS暴露与婴儿T细胞频率和功能之间的关联.
主要方法:
- 招募了母婴二,并在怀孕期间测量了母亲血清PFAS度 (PFOS,PFOA,PFNA,PFHXS).
- 婴儿淋巴细胞频率在出生时被评估,6个月和12个月使用质细胞计量.
- 线性混合效应模型分析了母亲的PFAS水平和CD4+T细胞亚群之间的关系,并对共变量进行调整.
主要成果:
- 胎内PFAS暴露与多个婴儿CD4+T细胞亚群的显著变化相关.
- 在12个月后,在T-毛囊辅助细胞 (Tfh) 和T-辅助细胞2 (Th2) 中观察到最明显的效应.
- 增加的母体PFOS水平与降低的Tfh和增加的Th2细胞百分比有关,其他PFAS也有类似的趋势.
结论:
- 母亲暴露于PFAS与婴儿T细胞区的细胞特异性变化有关.
- 这些变化涉及至关重要的CD4+T细胞亚群,对免疫调节至关重要.
- 需要进一步的研究,以了解PFAS诱导的T细胞变化对儿童免疫相关的不良健康结果的作用.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.6K
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.7K
相关概念视频
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
01:22Development of Immunocompetence
288
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
288