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Updated: Jun 6, 2025

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负面的BOLD响应在任务特异性方面超过了积极的响应,反映神经重新配置比功能连接更好

Saman Gholipour Picha^1,2, Seyed Hani Hojjati¹, Siddharth Nayak^1,3

¹Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, United States.

medRxiv : the preprint server for health sciences

|November 28, 2024

概括

在认知任务中,负 BOLD 响应 (NBR) 比正 BOLD 响应 (PBR) 更具任务特异性. 任务唤起的活动更好地反映了大脑的重新配置,而不是功能连接,增强对神经机制的理解.

科学领域:

认知神经科学认知神经科学
神经成像是一种神经成像.

背景情况:

了解认知任务期间的大脑活动至关重要.
脑反应的特异性,如负BOLD响应 (NBR) 和正BOLD响应 (PBR),是解释神经成像数据的关键.
任务唤起的活动和功能连接是常见的措施,但它们对特定任务的大脑变化的相对敏感性仍在争论中.

研究的目的:

为了比较NBR与PBR在认知任务中的任务特异性.
为了确定任务唤起的活动或功能连接是否更好地捕捉不同任务中的大脑重新配置.
提高对认知过程中神经机制的理解.

主要方法:

功能磁共振成像 (fMRI) 数据来自214名参与者执行12个认知任务.
使用Dice系数分析NBR和PBR的空间模式和任务特异性.
使用多会话层次贝叶斯模型 (MS-HBM) 评估功能连接,以比较对任务诱导的大脑变化的敏感性.

主要成果:

在所有任务中,NBR的任务特异性明显高于PBR (迪斯系数:NBR平均值0.44与PBR平均值0.67,p <0.001).
功能连接分析显示了跨任务的稳定默认模式网络 (DMN).
发现任务唤起的活动对任务特定的大脑重新配置比功能连接更敏感.

结论:

负 BOLD 响应 (NBR) 显然比正 BOLD 响应 (PBR) 更具任务特异性.
与功能连接相比,任务唤起的活动提供了更敏感的测量神经重新配置,具体用于认知任务.
这些发现强调了在认知神经科学研究中考虑NBR的重要性,以更深入地了解大脑功能.

关键词:

认知任务认知任务默认模式网络默认模式网络功能连接的功能连接性负面的 BOLD 响应积极的 BOLD 响应任务的具体性任务的具体性功能磁力共振成像 (fMRI) 是一种功能共振成像.

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