感知压力和皮质醇生物标志物之间的关联在主要是拉丁裔青少年中
Fatimata Sanogo1, Avaion Ruth1, Victoria K Cortessis1
1Keck School of Medicine of USC.
Research square
|November 28, 2024
概括
青少年的感知压力与每日皮质醇总量和白天斜率有不一致的联系,但与皮质醇唤醒反应或血清皮质醇没有联系. 为了更好的压力测量工具,需要进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 青少年健康 青少年健康
- 心理神经内分泌学心理学
背景情况:
- 在青少年中,感知压力和皮质醇生物标志物之间的关系尚不清楚.
- 皮质醇是一种关键的压力激素,在身体应对压力的反应中起着至关重要的作用.
研究的目的:
- 研究青少年感知压力与各种皮质醇生物标志物之间的关联.
- 通过感知应激量表 (PSS) 测量所感知的压力是否与血清皮质醇 (sCOR),皮质醇唤醒反应 (CAR),日间皮质醇斜率 (DCS) 和每日唾液皮质醇总量 (TDC) 相对应.
主要方法:
- 一项涉及229名青少年 (平均年龄15.8岁) 的研究.
- 使用14项感知压力尺度 (PSS) 评估感知压力.
- 测量的皮质醇生物标志物包括sCOR,CAR,DCS和TDC. 统计分析使用了基线和纵向关联的多变量和混合效应线性回归,以年龄,性别和BMI进行调整.
主要成果:
- 在基线时发现PSS和TDC之间存在显著的反向关联 (p=0.002).
- 在12周后观察到PSS和DCS之间存在显著的反向关联 (p=0.01).
- 在基线或12周的PSS和sCOR或CAR之间没有发现显著的关联,也没有在PSS和皮质醇生物标志物的纵向变化之间发现显著的关联.
结论:
- 青少年的感知压力与每日的皮质醇总量和每日皮质醇倾斜率存在不一致的关联.
- 通过PSS测量的感知压力并不始终与皮质醇唤醒反应或血清皮质醇水平相关.
- 这些发现强调了需要改进的仪器来测量感知压力,这些仪器对下丘脑-垂体-上腺 (HPA) 轴的功能敏感.
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