在COVID-19中的年龄和性别特定的中风流行病学
Youngran Kim1, Maria A Parekh2, Xiaojin Li2
1Department of Management, Policy and Community Health, School of Public Health, University of Texas Health Science at Houston, Houston, TX, United States.
Frontiers in stroke
|November 28, 2024
概括
COVID-19增加了中风风险,特别是急性缺血性中风 (AIS) 和脑内出血 (ICH),特别是在诊断后3天内. 高龄,男性性别和少数民族是COVID-19患者中风的重要危险因素.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- COVID-19 (冠状病毒疾病2019) 被认为是脑血管事件的独立风险因素,包括中风.
- 了解与COVID-19相关的特定年龄和性别相关的中风风险对于患者管理和公共卫生战略至关重要.
研究的目的:
- 为了确定在美国被诊断患有COVID-19的个人中风的年龄和性别特定发病率.
- 确定与COVID-19感染后中风发展相关的关键人口和临床风险因素.
主要方法:
- 一项回顾性队列研究利用了大型非识别电子健康记录 (EHR) 数据库,其中包括387,330名实验室确认的COVID-19患者.
- 脑卒中发生率 (急性缺血性脑卒中[AIS]和脑内出血[ICH]) 在COVID-19确诊后的180天内进行评估.
- 统计分析包括卡普兰-梅尔曲线,日志级别测试和多变量考克斯比例危险回归来估计相对风险.
主要成果:
- 在180天内,中风的总发病率为0.71%,AIS为0.65%,ICH为0.11%.
- 很大一部分中风 (57%) 发生在COVID-19诊断后3天内.
- 高龄 (≥65岁),男性性别和属于非裔美国人或西班牙裔族群的人与相对年轻人,女性和白人患者相比,风险相对较高.
结论:
- 在COVID-19之后的中风风险在诊断后的最初几天是最高的,并且随着时间的推移而减少.
- 男性性别,老年和少数民族是COVID-19患者中风的独立风险因素.
- 传统的中风风险因素在COVID-19感染的个体中放大了中风的风险,突出了需要警监测的必要性.
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