在孕期晚期和哺乳期服用母乳基托寡糖补充剂,可优化母猪的胎盘功能和21天大IUGR哺乳小猪的肠功能
Xintao Wang1,2, Tingting Fang1,2, Daiwen Chen1,2
1Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Frontiers in veterinary science
|November 28, 2024
概括
母亲用酸盐寡糖化物 (COS) 补充食,降低了猪的死胎和木乃伊. 在子宫内生长限制 (IUGR) 的小猪中,COS改善了胎盘功能和增强了肠道健康,促进了更好的产后发育.
科学领域:
- 动物科学动物科学
- 生殖生物学 生殖生物学
- 发展生物学 发展生物学
背景情况:
- 胎内生长限制 (IUGR) 是猪生产的一个重大问题,影响小猪的生存能力和生长.
- 酸盐寡糖化物 (COS) 正因其改善母亲和后代健康的潜力而受到研究.
- 了解COS对胎盘功能和小猪肠道健康的影响对于减轻IUGR至关重要.
研究的目的:
- 为了评估母猪在妊娠晚期和哺乳期对母猪的食奇多寡糖化物 (COS) 补充剂的疗效.
- 调查COS对母猪生产率,胎盘功能和子宫内生长限制 (IUGR) 小猪的肠道健康的影响.
- 确定COS是否可以减少死产,改善胎盘营养转移,增强肠道屏障功能和IUGR小猪的抗氧化能力.
主要方法:
- 30头母猪从怀孕85天到哺乳21天被分为控制组和补充COS (100毫克/公斤) 的组.
- 胎盘基因表达 (GLUT1,GLUT3,VEGFA),氧化应激标志物 (MDA,GSH) 和乳头基因/蛋白质表达 (MUC2,奥克卢丁,克劳丁1,IL-10) 在IUGR小猪身上进行了分析.
- 记录了死胎,木乃伊和小猪生长参数.
主要成果:
- 补充COS显著减少了死胎和木乃伊.
- COS上调了胎盘GLUT1,GLUT3和VEGFAmRNA,并降低了MDA,同时增加了IUGR猪仔中的GSH.
- 在IUGR小猪中,COS增加了头MUC2,occludin,claudin1和IL-10mRNA表达,同时降低了MDA水平.
结论:
- 母亲饮食中的COS补充剂有效地减少了母猪的死产和木乃伊.
- 在IUGR小猪中,COS增强了胎盘功能和抗氧化能力,可能改善营养转移.
- 补充COS对哺乳IUGR小猪的肠道屏障完整性,消化功能和免疫状态产生积极影响.
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