血小板与高密度脂蛋白胆固醇比率与未来中风风险之间的关联:基于查尔斯的全国队列研究
Xin Hou1, Meibao Zhu1, Zhenghao Zhu1
1Department of Cardiology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Frontiers in neurology
|November 28, 2024
概括
较高的血小板与高密度脂蛋白胆固醇 (PHR) 比率水平与中风风险增加有关. 这一发现有助于识别高风险中风的个体,有助于预防策略.
科学领域:
- 心血管研究研究心血管研究
- 生物标志物发现发现
- 流行病学 流行病学
背景情况:
- 血小板与高密度脂蛋白胆固醇 (PHR) 的比率被认为是一种潜在的炎症生物标志物,已与冠状动脉疾病严重程度建立联系.
- 现有研究对PHR和中风发病率之间的关联提供了有限的证据,需要进一步调查.
研究的目的:
- 调查血小板与高密度脂蛋白胆固醇 (PHR) 的比率与中风风险之间的潜在关联.
- 为了确定PHR是否可以作为中风发病率的预测标记.
主要方法:
- 利用了2011年至2018年的中国健康与退休长度研究 (CHARLS) 的数据.
- 包括5,872名没有中风病史的参与者,分为四个基线PHR四分位数.
- 采用Cox比例危险回归,限制立方线和子组分析来评估中风的结果.
主要成果:
- 在77.5个月的中位数随访期间,发生了390次中风.
- 与最低四分位数 (HR 1.49) 相比,PHR四分位数最高的参与者患中风的风险增加了49%.
- 经过调整后的分析证实了较高的PHR水平与中风风险增加之间存在显著的正线性关联.
结论:
- 升高的PHR水平与较高的中风风险显著相关.
- PHR可以作为一种有价值的工具来识别患中风高风险的个体.
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