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Updated: Jun 6, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

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合成,结构特征和单核和双核Pd (II) 复合物的抗癌潜力N-{2-pyridyl) thiourea

Shivendra Kumar Pandey1, Sandeep Kumar2, Swati Singh1

  • 1Department of Chemistry, Banaras Hindu University, Varanasi 221005, India. mkbharty@bhu.ac.in.

Dalton transactions (Cambridge, England : 2003)
|November 28, 2024
PubMed
概括

新的复合体对结肠和乳腺癌细胞表现出强大的抗癌活性. 双核复合物[Pd(M3MPyThU) Cl]2对HT-29细胞特别有效,诱导细胞亡,对健康细胞的毒性降低.

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相关概念视频

Phase II Reactions: Miscellaneous Conjugation Reactions01:19

Phase II Reactions: Miscellaneous Conjugation Reactions

Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
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Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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