小孩子接受大剂量,而大孩子接受低剂量阿莫西西林每公斤
Katelyn S Stenger1, Loren G Yamamoto2,3
1Hawai'i Pacific Health Summer Student Research Program, Honolulu, HI, USA.
Clinical pediatrics
|November 28, 2024
概括
儿童用阿莫西西林的剂量因年龄和体重而异,年龄较大的儿童接受的剂量低于推的mg/kg. 这项研究强调了阿莫西西林在儿童中给予的关键差异,这可能会影响治疗疗效.
科学领域:
- 儿科药理学 儿科药理学
- 传染病治疗 传染病治疗
- 抗生素剂量指南 抗生素剂量指南
背景情况:
- 肺炎球菌对青素耐药性的增加导致了更高的阿莫西西林剂量建议 (80-90 mg/kg/d).
- 医生经常犹是否超过成人阿莫西西林剂量,这可能与儿科指导方针发生冲突.
- 儿童的肥胖症可能导致他们在年轻时达到最大剂量.
研究的目的:
- 为了检查基于儿童患者的年龄和体重的阿莫西西林剂量的差异.
- 调查当前的阿莫西西林剂量实践是否与高剂量治疗的建议保持一致.
主要方法:
- 对3620名儿科患者进行了回顾性图表审查,这些患者接受了针对感染的阿莫西西林处方.
- 分析的重点是根据建议接受高剂量阿莫西西林的患者.
- 使用线性回归来评估年龄,体重和处方阿莫西西林剂量 (mg/kg/d) 之间的相关性.
主要成果:
- 在年龄/剂量和体重/剂量之间发现了显著的负相关性.
- 较大的儿童和年龄较大的儿童获得明显较低的阿莫西西林剂量 (mg/kg/d).
- 大多数60公斤以上的患者接受的剂量低于40毫克/公斤/天,许多儿童在15-20公斤左右超过了成人最大剂量.
结论:
- 对于需要高剂量治疗的感染,老年儿童经常被处方每公斤亚治疗剂量的阿莫西西林.
- 儿科患者的阿莫西西林剂量存在明显差异,年龄较大/体型较大的儿童可能服用不足剂量.
- 目前的剂量实践可能会导致因年龄和体重的变化而导致不理想的治疗结果.
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