运动压力回声心电图显示COVID-19住院后左心室功能受损,没有明显心肌炎:试点研究
Robert E Goldstein1,2,3, Edward A Hulten2, Thomas B Arnold1,4
1Military Cardiovascular Outcomes Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
COVID-19幸存者在压力下表现出心脏功能减弱,即使没有先前的心脏问题. 运动压力心声扫描揭示了这些隐藏的心脏变化,影响长期健康.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 身体生理学 身体生理学
背景情况:
- 标准的临床检测往往错过了COVID-19住院后持续存在的心脏问题.
- 在COVID-19后的微妙心脏变化可能会增加心脏不良事件的风险.
- 在压力期间评估心脏功能对于理解恢复至关重要.
研究的目的:
- 为了评估COVID-19康复患者 (RP) 的心脏功能,使用运动应激心声学 (ESE).
- 为了比较RP的心脏表现与身体压力下的健康受试者 (HS).
- 为了确定常规检测无法检测到的残留心脏异常.
主要方法:
- 15名没有心肌炎的COVID-19康复患者 (30-63岁) 接受了ESE.
- 运动期间的RP性能与健康受试者的公布数据进行了比较.
- 关键指标包括左心室射出分数, mitra 输入速度和 E/e' 比率.
主要成果:
- 在峰值压力时,RP的平均左心室喷射分数显著较低 (67%vs73%).
- RP显示较高的峰值早期心肌流入速度/早期心肌环状速度 (E/e',9.1与6.6),表明扩张功能受损.
- 在压力下的RP中,ESE发现心脏功能缩和扩张功能下降,与HS不同.
结论:
- 运动压力回声心脏图显示了COVID-19幸存者的显著残留心脏功能障碍.
- 这些发现表明潜在的自主功能障碍,微血管疾病或COVID-19后间歇性变化.
- 识别这些亚临床心脏异常对于患者的管理和预后至关重要.
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