生物类似单克隆抗体用于成人癌症治疗
Tais F Galvao1, Annemeri Livinalli1, Luciane C Lopes2
1School of Pharmaceutical Sciences, Universidade Estadual de Campinas, Campinas, Brazil.
The Cochrane database of systematic reviews
|November 28, 2024
概括
癌症生物相似疗法,包括贝瓦齐祖马布,利图西马布和特拉斯图祖马布,表现出与其原始药物相比的有效性和安全性. 这份对随机对照试验的综述表明,无进展生存,总生存和不良事件的结果相似,支持它们在癌症治疗中的使用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 生物仿制药是类似于原始产品的生物药物.
- 在癌症治疗中,可使用贝瓦齐祖马布,利图西马布和特拉斯图祖马布的生物类似药.
- 证据综合对于癌症生物类似药的比较有效性和安全性至关重要.
研究的目的:
- 在成人癌症患者中评估生物类似单克隆抗体与原始药物的益处和危害.
- 综合有关癌症生物类似药的比较有效性的证据.
主要方法:
- 对头对头随机对照试验 (RCT) 的系统审查.
- 搜索了主要的文献和临床试验数据库,截至2024年2月.
- 使用Cochrane的RoB 1工具评估偏差风险和使用GRADE的证据确定性.
主要成果:
- 55个RCT (22,046名成年人) 包括贝瓦齐祖马布,利图西马布和特拉斯图祖马布生物类似药.
- 与原始药物相比,贝瓦西祖马布,利图西马布和特拉斯图祖马布生物类似药可能具有类似的疗效和安全性.
- 大多数结果的中等确定性证据;不精确是关键限制.
结论:
- 癌症生物仿制药 (贝瓦西祖马布,利图キシ马布,特拉斯图祖马布) 的临床效果与它们的原始药物相似.
- 有证据表明,类似的无进展生存率,整体生存率和不良事件概况.
- 进一步的研究可能会澄清所有生物相似比较的生命质量等结果.
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