在美国的一个大型队列中,早期的月经特征和妊娠期糖尿病
Zifan Wang1, Donna D Baird2, Michelle A Williams3
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Paediatric and perinatal epidemiology
|November 28, 2024
概括
早期初潮和延长月经周期规律的时间增加了妊娠糖尿病 (GDM) 和其复发的风险. 这些年轻人的月经特征可能是GDM风险的早期指标.
科学领域:
- 生殖健康 生殖健康
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 生命早期的月经周期特征 (MCC) 和妊娠糖尿病 (GDM) 之间的关系尚不清楚.
- 研究这些关联可以识别GDM风险的潜在早期标志物.
研究的目的:
- 检查生命早期MCC和第一次怀孕中的GDM之间的联系.
- 评估跨多胎妊娠和GDM复发的关联.
- 为了确定GDM的潜在早期生命指标.
主要方法:
- 基于美国的数字队列 (n=30,473) 的分析,其中有自我报告的MCC和GDM历史.
- 初潮时的年龄和周期规律的时间 (包括延长周期规律时间,PTTR) 的分类.
- 统计建模 (Poisson回归,GEE,多项逻辑回归) 调整了混因子,对缺失数据进行了多次归算.
主要成果:
- 早期初潮 (<11年) 与第一次怀孕 (RR 1.34),跨怀孕 (RR 1.24) 和复发 (OR 1.51) 的GDM风险增加有关.
- 延长时间到规律性 (PTTR) 与第一次怀孕 (RR 1.22) 和跨怀孕 (RR 1.16) 中更高的GDM风险有关.
- 此外,PTTR也显示了GDM复发风险增加的趋势 (OR 1.19).
结论:
- 较早的初潮和延长月经周期规律的时间与患GDM的风险更高有关.
- 这些发现表明,童年和青春期的月经周期特征可以作为GDM的早期预警信号.
- 进一步的研究可以探索针对这些早期标记物的干预措施.
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