基于代谢功能障碍相关的脂肪性肝病和非酒精性脂肪性肝病的糖尿病预测的比较:ELSA-巴西研究
Gabriela Wünsch Lopes1, Scheine Leite Canhada1, Rodrigo Citton Padilha Dos Reis1,2
1Programa de Pós-graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Cadernos de saude publica
|November 28, 2024
概括
该研究发现,非酒精性脂肪性肝病 (NAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 的定义同样预测了巴西成年人2型糖尿病的发生率. 在不同种族/肤色群体中,相关性是一致的.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个新定义,包含了代谢标准.
- 了解这些定义对糖尿病的预测价值至关重要.
研究的目的:
- 为了比较NAFLD和MASLD定义对巴西成年人2型糖尿病发病率的预测能力.
- 调查NAFLD/MASLD与糖尿病之间的关联是否在自我声明的种族/肤色群体之间有所不同.
主要方法:
- 针对7073名巴西公务员 (35-74岁) 的前性队列研究 (ELSA-巴西).
- 以超声波为基础的肥胖症定义的NAFLD;以肥胖症加上至少一个心脏代谢因子定义的MASLD.
- 通过自我报告,药物和血糖测试在9.4年内确定的2型糖尿病.
- 考克斯的比例危险模型用于评估关联.
主要成果:
- 在基线时,33.9%的人患有NAFLD,32.5%的人患有MASLD.
- 在9.4年内,NAFLD显示糖尿病发病率增加了78% (HR=1.78),而MASLD显示88%的增加 (HR=1.88).
- 在种族/肤色组中,NAFLD/MASLD和糖尿病发病率之间的关联是相似的 (p-相互作用>0.05).
结论:
- 在这个巴西队列中,NAFLD和MASLD的定义对2型糖尿病发病率具有相似的预测能力.
- 这些肝病与糖尿病之间观察到的关联在不同种族群体中是一致的.
- 这些发现支持NAFLD和MASLD定义在识别患糖尿病风险的个人的有用性.
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