在大鼠前列腺腺中,雄激素受体和氨酸酸化蛋白表达之间的关联
C Kamollerd1, S Uopasai1, T Kamollerd2
1Khon Kaen University, Faculty of Veterinary Medicine, Department of Anatomy, Khon Kaen, Thailand.
Brazilian journal of biology = Revista brasleira de biologia
|November 28, 2024
概括
前列腺功能依赖于和雄激素受体 (AR) 信号传递. 这项研究表明,丸激素水平和AR表达的变化与前列腺发育和割期间改变的铁酸化 (TyrPho) 蛋白质水平相关.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 哺乳动物前列腺合成性物质,其功能取决于成熟和-受体 (AR) 信号.
- 铁酸化 (TyrPho) 蛋白质涉及到安卓素依赖器官内的分泌途径.
- 在前列腺中AR和TyrPho蛋白表达之间的关系在很大程度上仍未被探索.
研究的目的:
- 调查大鼠前列腺中雄激素受体 (AR) 和铁酸化 (TyrPho) 蛋白表达之间的关联.
- 检查割对前列腺发育期间AR和TyrPho蛋白水平的影响.
主要方法:
- 雄性大鼠被分为青春期前,假手术和割 (割后3天和7天) 的组.
- 测量了血清丸激素水平.
- 组织学,AR局部化和TyrPho和AR蛋白表达在不同的前列腺叶子中被分析.
主要成果:
- 割导致无法检测的丸激素水平和减少的AR表达,伴随着前列腺大小的减少.
- 特定的TyrPho蛋白水平 (例如,48 kDa) 在腹叶中增加,而其他水平在各叶和治疗组中下降.
- 在割后,观察到TyrPho蛋白表达在腹腔,背侧和前前列腺叶的显著变化.
结论:
- 水平和AR表达与前列腺TyrPho蛋白表达密切相关.
- 这些发现突显了雄激素信号在调节前列腺发育期间和响应割时TyrPho蛋白质中的作用.
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