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对于年长的成年人来说,标准化定义对服用长期药物如二类药物和Z类药物的处方至关重要. 90天间隙或"光环"时期比较短的间隙更好地捕捉到停产,并且发行数据比订单数据更准确.

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科学领域:

  • 老年学是一门学科.
  • 药理学 药理学是指药理学的学科.
  • 医疗信息学 医疗信息学

背景情况:

  • 降低处方 (停止或减少药物) 可以改善老年人的健康状况.
  • 对于电子健康数据的标准化措施缺乏用于减轻治疗的研究.
  • 医疗保健系统之间的数据类型和可用性的差异阻碍了研究.

研究的目的:

  • 开发和应用使用电子健康数据对慢性药物使用和停止使用的标准化定义.
  • 评估不同类型的数据 (药物订单与处方) 和定义参数对描述估计的影响.
  • 评估在美国各种医疗保健系统中对老年人进行二和Z药物抑郁症的处方.

主要方法:

  • 对65岁以上慢性使用二或Z药物 (2017-2019) 的成年人进行了回顾性队列研究.
  • 根据药物订单和/或药品分发,制定慢性使用和停药的定义.
  • 对不同间隙长度和30天"光环"停药期的分析,比较订单与发药数据.

主要成果:

  • 慢性二胺/Z药物使用影响1.6%-2.6%的老年人 (N=6775).
  • 停药率因定义和地点而有很大差异 (6%-49%).
  • 90天间隔或"光环"降低了停药估计;发行数据显示,停药率高于订单数据.

结论:

  • 间隔≥90天或"光环"时期可能提供更准确的断药估计.
  • 与发行数据相比,药物订单低估了停药的可能性.
  • 需要进一步的工作来适应这些定义用于其他药物类别和环境.