不同的超声速率反映了甲状腺癌中的性别差异
Sara Fernandes-Taylor1, Erin J Aiello Bowles2, Manasa Venkatesh3
1Division of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Thyroid : official journal of the American Thyroid Association
|November 28, 2024
概括
甲状腺癌的发病率在女性中较高,但这项研究发现超声波触发细针吸收活检 (FNAB) 在男性中更常见. 甲状腺超声波率的性别差异可能导致甲状腺癌发病率的性别差异.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 甲状腺癌的发病率在女性中更高,这种差异随着时间的推移而扩大.
- 甲状腺癌的性别差异还没有得到充分的研究,尤其是在私人保险成年人的诊断测试方面.
- 甲状腺癌在私人保险成年人中最常见.
研究的目的:
- 评估甲状腺超声波,细针吸收活检 (FNAB) 和按性别的甲状腺癌发病率之间的关联.
- 调查诊断测试在甲状腺癌性别差异中的作用.
- 分析超声波使用趋势,FNAB率和按性别检测癌症的趋势.
主要方法:
- 对接受甲状腺超声波检查的成年受试者 (1997-2019) 进行了长度回顾性队列研究.
- 电子计费索赔与瘤注册诊断的数据链接.
- 普森回归建模来评估性别和超声波触发的FNAB之间的关系,调整共变量.
主要成果:
- 在1997年至2019年期间,超声波和FNAB的发病率在两性之间显著增加,女性的绝对发病率更高.
- 在男性中,每次超声波的FNAB略高 (Adj率比=1.06).
- 每个FNAB的癌症发病率在性别之间是相似的 (0.06),尽管女性的总体癌症发病率更高.
结论:
- 甲状腺超声波利用中的性别差异似乎是甲状腺癌发病率中观察到的性别差异的重要驱动因素.
- 超声波触发的FNAB在男性中更常见的发现挑战了对基于性别的甲状腺癌差异的传统理解.
- 虽然FNAB和癌症存在人口层面的差异,但接受超声波的个体之间的差异很小.
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