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脑下和脑下深层大脑刺激对帕金森病患者的言语和声音的影响

Frank Müller¹, Julie Cläre Nienstedt², Carsten Buhmann³

¹Department of Voice, Speech and Hearing Disorders, Center for Clinical Neurosciences, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. f.mueller@uke.de.

Journal of neural transmission (Vienna, Austria : 1996)

|November 28, 2024

概括

对帕金森病 (PD) 的深度大脑刺激 (DBS) 显示了对言语和语音质量的轻微,无意义的影响. 亚thalamic (STN-DBS) 和联合 (STN+SNr-DBS) 刺激都是安全的,但与DBS OFF相比,没有显著改善整体组语音参数.

科学领域:

神经学神经学
语音语言病理学语音语言病理学
生物医学工程生物医学工程

背景情况:

帕金森病 (PD) 显著影响言语和声音.
深度大脑刺激 (DBS) 是PD运动症状的主要治疗方法.
DBS对言语等非运动症状的影响需要进一步研究.

研究的目的:

为了比较脑下核深度大脑刺激 (STN-DBS) 与结合STN和黑色物质,Spars reticulata (STN+SNr-DBS) 对PD患者的言语和声音的影响.
为了对DBS关闭条件来评估这些影响.

主要方法:

一项受控,随机,双盲,交叉试验,涉及15名双边STN-DBS的PD患者.
使用主观问卷 (VAS,VHI,SHI) 和客观音频指标 (MPT,AVQI,F0,语调,音节速率,阅读时间) 的语音和语音分析.

主要成果:

与DBS OFF相比,STN-DBS和STN+SNr-DBS都显示出异质效应,与DBS OFF相比,个体语音质量和语调的轻微,不显著的改善.
在各种刺激条件下,在客观语音参数中没有观察到显著的变化.
在STN-DBS和STN+SNr-DBS之间没有发现显著差异.

结论:

与运动改善相比,DBS在PD患者的言语和声音方面提供了轻微,无意义的好处.
无论是STN-DBS还是STN+SNr-DBS都是安全的,并且在语音制作方面都能很好地容忍.
目前的DBS策略并没有违反语音干预.

关键词:

在 DBS 中,DBS 是 DBS 的代名词.帕金森病是帕金森氏症的一种疾病.美国人SNR 标签: 美国 STN STN 演讲演讲演讲声音的声音的声音的声音

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