新生儿便微生物组的组成,有或没有尿路感染
Hilla Bahat1,2, Michal Paret3,4, Atara Uzan5
1Department of Pediatrics, Shamir Medical Center, 70300, Zerifin, Israel. hbahat@shamir.gov.il.
Pediatric nephrology (Berlin, Germany)
|November 28, 2024
概括
与没有尿路感染的发烧婴儿相比,患有尿路感染的发烧婴儿表现出明显的肠道微生物群差异. 这表明肠道微生物组可能在婴儿尿路感染的发展中发挥作用.
科学领域:
- 微生物学 微生物学
- 新生儿健康 新生儿健康
- 胃肠病学 胃肠病学
背景情况:
- 大多数婴儿发烧性尿路感染 (UTI) 缺乏解剖学风险因素.
- 便微生物群是常见的尿路感染病原体的潜在来源.
- 调查发烧的新生儿有或没有尿路感染的肠道微生物群的差异至关重要.
研究的目的:
- 为了确定肠道微生物群的组成是否在2个月以下的发烧新生儿和无尿路感染之间有所不同.
- 确定新生儿尿路感染的潜在非解剖学风险因素.
主要方法:
- 展望,案例控制,试点研究.
- 用于表征肠道微生物群的16S核糖体RNA扩增序列.
- 队列包括42名发烧的新生儿 (17名有尿路感染,25名没有尿路感染).
主要成果:
- 尿道感染和非尿道感染组之间的β多样性 (组间相似性) 的显著差异 (p=0.016).
- 普遍存在的细菌种类相对丰富性的明显差异.
- 在UTI组中,特定的属性被丰富,而其他属性则在非UTI组中占主导地位;在UTI组中,链球菌的代表性不足.
- 没有观察到α多样性 (样本内丰富性) 的显著差异.
结论:
- 患有尿路感染的发烧新生儿与没有尿路感染的新生儿相比,表现出不同的便微生物群组成 (β-多样性).
- 肠道微生物群的α多样性在两组之间没有差异.
- 需要进行更大规模的研究来证实这些发现,并探索潜在的临床应用.
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