患有复发性复发性多发性硬化症的患者在疾病早期表现出加速的全脑体积和thalamic体积损失
Roland Opfer1, Matthias Schwab2, Sabine Bangoura3
1jung diagnostics GmbH, Hamburg, Germany. roland.opfer@jung-diagnostics.de.
Neuroradiology
|November 28, 2024
概括
在早期多发性硬化症 (MS) 阶段,大脑和丘脑体积损失加速,后来减慢. 这一发现强调了早期干预对于复发性复发性多发性硬化症 (RRMS) 患者的重要性.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医学研究 医学研究
背景情况:
- 调查复发性复发性多发性硬化症 (PwRRMS) 患者每年全脑体积损失 (BVL/年) 和乳头体积损失 (ThalaVL/年) 的情况.
- 了解疾病进展动态对于有效的治疗策略至关重要.
研究的目的:
- 在PwRRMS中量化和比较BVL/年和ThalaVL/年,跨不同疾病持续时间.
- 要区分MS相关的和年龄相关的体积变化.
主要方法:
- 分析了来自256名PwRRMS和195名健康个体的纵向MRI数据.
- 雅可比安整合计算了BVL/年和ThalaVL/年;线性回归分离了MS相关和年龄相关的组件.
- 为了进行比较,PwRRMS被分为早期 (≤6年) 和晚期 (>6年) 疾病阶段.
主要成果:
- 早期RRMS患者的MS相关BVL/年显著更高 (-0.21%) 与晚期患者相比 (-0.06%).
- 与MS相关的ThalaVL/年差异更为明显,早期阶段的患者比后期阶段的患者显示出更大的损失 (-0.39%).
结论:
- 与MS相关的大脑和乳头体积损失在RRMS的早期阶段加速,并随着时间的推移减缓.
- 这些发现支持这样的假设,即MS的早期治疗干预可能会导致更好的患者结果.
相关概念视频
01:19Multiple Sclerosis l: Introduction
31
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
31
01:23Alzheimer Disease ll: Pathophysiology
42
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
42