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Updated: Jun 6, 2025

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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基因组序列和损伤依赖的线粒体转录因子A (TFAM) -DNA结合调节DNA修复活动和产品

Kathleen Urrutia1, Yu Hsuan Chen1, Jin Tang1

  • 1Department of Chemistry, University of California, Riverside, CA 92521, USA.

Nucleic acids research
|November 28, 2024
PubMed
概括

线粒体转录因子A (TFAM) 度和DNA修饰,如8-oxodG,复杂调节线粒体DNA修复酶,影响线粒体功能.

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Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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