在RCSB蛋白质数据库中探索实验确定PDB结构和计算结构模型的更新资源
Stephen K Burley1,2,3,4,5,6, Rusham Bhatt1,2, Charmi Bhikadiya5
1Research Collaboratory for Structural Bioinformatics Protein Data Bank, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Nucleic acids research
|November 28, 2024
概括
结构生物信息学蛋白质数据库 (RCSB PDB) 的研究实验室现在为超过227,000个生物结构和100万个蛋白质模型提供了增强的工具和可视化. 探索具有结构生物学研究新特征的类似蛋白质.
科学领域:
- 结构生物学 结构生物学
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 结构生物信息学蛋白质数据库研究合作室 (RCSB PDB) 是全球蛋白质数据库 (PDB) 档案的美国数据中心.
- 它通过其RCSB.org网站提供了通过实验确定的原子级3D生物结构和计算蛋白质模型的访问权限.
研究的目的:
- 报告RCSB.org.org上可用的工具和可视化功能中的重大补充.
- 增强探索生物结构数据和计算蛋白质模型的用户体验.
主要方法:
- 将新工具和可视化功能集成到 RCSB.org 平台中.
- 根据减少冗余的组组织查询结果.
- 开发摘要页面,用于探索类似蛋白质的组.
- 引入新的程序工具和增强培训机会.
主要成果:
- 现在,RCSB.org提供了超过227,000个经过实验确定的3D生物结构.
- 有超过100万种蛋白质的计算结构模型 (CSM),包括用于人类,模型生物,病原体和作物植物的模型.
- 新功能支持3D结构图案搜索,并促进蛋白质组的探索.
结论:
- 增强的RCSB.org门户提供了结构生物学研究的扩展资源.
- 新功能提高了数据可访问性,探索性和对生物结构信息的程序访问性.
- 这些进展支持了广泛的生物研究,包括关于人类健康和适应气候变化的研究.
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