在视觉食物提示呈现期间,胰岛素诱导海马体功能连接的性别差异
Sixiu Zhao1,2, Ralf Veit1,2, Lorenzo Semeia1,2
1Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
The Journal of clinical endocrinology and metabolism
|November 28, 2024
概括
中央胰岛素影响与食欲控制相关的大脑连接. 这种影响在性别之间有所不同,可能受到性激素的影响,影响饥饿和食欲.
科学领域:
- 神经内分泌学神经内分泌学
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 中央胰岛素调节食欲和认知,具有性别特异性的影响.
- 海马在食欲控制中起着关键作用,受到胰岛素的影响.
- 胰岛素,海马对食物线索的反应和性激素之间的相互作用还不太清楚.
研究的目的:
- 为了研究鼻内胰岛素在食物提示呈现期间对海马体功能连接 (FC) 的影响.
- 探索性和性激素在胰岛素对海马FC的影响中的作用.
- 为了确定胰岛素调节的海马体FC是否与饥饿和食物渴望的变化有关.
主要方法:
- fMRI用于评估60名参与者 (30名女性) 经过鼻内胰岛素或安慰剂后的海马体的基于任务的FC.
- 采用了一个主体内部的随机设计.
- 探索性分析检查了13名绝经前妇女的海马FC和雌醇/孕激素水平之间的关系.
主要成果:
- 鼻内胰岛素增加了海马与前额叶皮层的FC,减少了饥饿和渴望,不论性别.
- 观察到海马体FC到状回形的性别特异性差异:男性显示胰岛素增加了FC,而女性显示减少了FC.
- 在更年期前的妇女中,胰岛素对海马 - 卡尔卡林环 FC 的作用与黄阶段中雌激醇/孕的比率有负相关性.
结论:
- 中央胰岛素调节海马FC到大脑区域,在暴露于高热量食物线索期间参与抑制控制.
- 海马网络可能会调解胰岛素的厌食效应.
- 在海马-视觉皮层连接中观察到的性别差异可能受到性激素的影响.
相关概念视频
Dietary Connections
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used as energy sources to produce...
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Hormones Regulating Blood Glucose
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
Gastric Emptying
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...


