传统的风险因素,最佳的心血管健康和高脂蛋白 (a)
Alexander C Razavi1, Mikaila P Reyes2, John T Wilkins3
1Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA.
European journal of preventive cardiology
|November 28, 2024
概括
保持最佳的生活方式
科学领域:
- 心血管疾病流行病学
- 脂蛋白 (a) 和动脉样硬化研究
- 预防性心脏病学 预防性心脏病学
背景情况:
- 脂蛋白 (Lp) 是动脉样硬化心血管疾病 (ASCVD) 的遗传决定性风险因素.
- 传统的风险因素和生活方式得分,如Life's Simple 7 (LS7),对于预防ASCVD至关重要.
- Lp(a) 水平与生活方式干预对ASCVD风险的有效性之间的相互作用尚未完全理解.
研究的目的:
- 通过LS7得分量化的传统风险因素负担与事件ASCVD之间的关联.
- 为了检查这种关系在不同的水平的脂蛋白[Lp[a].
主要方法:
- 从多民族动脉样硬化研究中分析了6,676名参与者,没有先前的ASCVD.
- 评估Lp(a) 水平 (<30,30-49,>50 mg/dL) 和LS7得分 (差,平均,最佳).
- 根据人口统计学和治疗方法调整的Cox比例危险回归模型,随访时间中位数为17.7年.
主要成果:
- 患有高Lp (a) (>50 mg/dL) 的个体在所有LS7类别中表现出更高的绝对ASCVD事件率.
- 最佳的LS7得分与ASCVD风险显著降低有关,无论Lp (a) 水平如何.
- 优良的LS7与较差的LS7的危险比率在Lp (a) 层中从0.12到0.45不等,这表明风险大幅降低.
结论:
- 在没有临床ASCVD的个体中,达到最佳的LS7得分显著降低了ASCVD风险,无论他们的Lp (a) 水平如何.
- 这些发现强调了健康的生活方式选择和强有力的ASCVD风险因素管理的重要性,特别是在Lp升高的人群中.
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