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未加的,插即用的临床前心脏CEST-MRI使用辐射FLASH与细分和度

Jonah Weigand-Whittier¹, Michael Wendland², Bonnie Lam¹

¹Department of Bioengineering, University of California Berkeley, Berkeley, California, USA.

Magnetic resonance in medicine

|November 28, 2024

概括

这项研究引入了一种用于临床前心脏化学交换和转移 (CEST) MRI 的新方法,消除了对心电图 (ECG) 或呼吸道门的需求. 这种新方法简化了心脏CEST-MRI采集,并减少了小鼠的测量变化.

科学领域:

生物医学成像技术生物医学成像技术
磁共振成像 (MRI) 是一种磁共振成像技术.
分子成像学分子成像学

背景情况:

临床前的心脏CEST-MRI由于T1变化,射频干扰和心脏/呼吸系统运动而具有挑战性.
传统的检测方法 (心电图,呼吸) 在心脏MRI中带来了复杂性和错误的可能性.
准确量化CEST对比度 (胺,Cr) 对于临床前心脏研究至关重要.

研究的目的:

开发和验证一种未公开的方法,用于小鼠的临床前心脏CEST-MRI.
评估简化心脏CEST-MRI采集而不需要门的可行性.
用封闭式和非封闭式方法获得的定量CEST对比进行比较.

主要方法:

采用了一种新的细分和模块,具有辐射FLASH读数和金角进展.
实现了稳定状态和,并在格子和重建过程中主导了对比度.
在健康小鼠中采用封闭和未封闭的方法在各种B1值下获得Z光谱.

主要成果:

门式和非门式方法之间没有观察到胺,Cr或磁化转移CEST对比度的显著差异.
在不复杂量化的情况下,确定了胺和Cr对比度的最佳和功率为1.8μT.
无线射线FLASH获取显著降低了CEST对比度测量的变异性 (p < 0.01).

结论:

开发的无线方法使得在小鼠心肌中可靠的CEST映射成为可能.
定量CEST对比与封闭序列一致,差异明显减少.
这种方法提高了临床前心脏CEST-MRI的可访问性,用于更广泛的研究应用.

关键词:

心脏成像 - - 心脏成像化学交换和转移化学交换和转移临床前成像学临床前成像序列设计设计的设计.

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