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作为癌症选择性光传感器的共价有机框架诱导挥发性有机化合物

Vaishnavi Mekkeparambath¹, M M Sreejaya¹, Sreelekshmi M¹

¹Department Chemistry, Institution Amrita Vishwa Vidyapeetham Address 1 Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala 690525, India.

Chembiochem : a European journal of chemical biology

|November 28, 2024

概括

联有机框架 (COFs) 提供精确,非侵入性光检测与癌症等疾病相关的挥发性有机化合物 (VOCs). 本综述详细介绍了COF合成和早期疾病诊断的机制.

科学领域:

材料科学材料科学材料科学
分析化学分析化学
生物医学工程生物医学工程

背景情况:

甲和等挥发性有机化合物 (VOC) 是癌症和糖尿病等疾病的生物标志物.
早期疾病诊断需要高精度,非侵入性检测方法.
使用先进材料的光传感是一种有前途的VOC检测方法.

研究的目的:

审查设计用于选择性检测与疾病相关的VOCs的共价有机框架 (COFs) 的合成.
阐明COF和目标VOC之间的相互作用机制,以提高检测.
为突出基于COF的光传感用于早期疾病诊断的最新进展.

主要方法:

使用具有可调节结构和 imine 连接器的 COF,通过结和电荷转移进行选择性 VOC 结合.
设计COF框架,具有特定的捐赠-接受单位,以与富电子和电子贫穷的VOC相互作用.
审查有关COF在癌症相关VOC光感应中的合成和应用的文献.

主要成果:

COF显示出对各种VOC的选择性和敏感光检测的潜力.
伊米因结合的COFs有效地与原始的VOCs (例如,乙醇) 和化物相互作用.
量身定制的COF结构允许特定的电荷转移相互作用来检测各种VOC.

结论:

氧化是一种非常有前途的材料,用于开发用于早期疾病检测的先进光传感器.
了解COF-VOC相互作用机制对于设计下一代诊断工具至关重要.
本综述提供了基于COF的VOC传感生物医学应用的全面概述.

关键词:

生物感应生物感应癌症的诊断癌症的诊断共价有机框架• 挥发性有机化合物光探测器的光探测器

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