在牙周炎中激活泌尿酸酶等离子素激活剂/泌尿酸酶等离子素激活剂受体系统:一项病例对照研究
Ahmed Khudhur1, Christopher Dowson2, Susan M Bissett2
1Department of Oral and Maxillofacial Surgery, College of Dentistry, Mosul University, Mosul, Iraq.
International journal of dental hygiene
|November 28, 2024
概括
唾液分析显示,在牙周炎患者中,泌尿酸酶等离子激素激活剂 (uPA) 和其受体 (uPAR) 的水平显著更高. 这些发现表明,uPA/uPAR可能作为牙周病的潜在唾液生物标志物.
科学领域:
- 生物化学 生化学
- 口腔生物学 口腔生物学
- 分子医学是分子医学.
背景情况:
- 塑原激活 (PA) 系统,特别是尿酶塑原激活器/尿酶塑原激活器受体 (uPA/uPAR) 系统,参与各种生理过程,包括伤口愈合和组织重塑.
- 对uPA/uPAR系统的调节失调已涉及到许多疾病状态,突出其在病理条件中的潜在作用.
研究的目的:
- 在被诊断患有牙周炎的患者中调查uPA和UPAR的唾液度和活性.
- 确定牙周炎的潜在唾液生物标志物,并探索新的病原性关系.
主要方法:
- 从169名参与者 (103名患有牙周炎,66名健康对照) 收集了唾液样本.
- 使用多重蛋白质测定与近距离延伸分析量化uPA和uPAR水平,并通过ELISA进行验证.
- 使用度测定法测量唾液uPA活性.使用度测定法测量唾液uPA活性.
主要成果:
- 与健康个体相比,牙周炎患者的唾液中uPA (4.0倍) 和UPAR (2.5倍) 度显著更高 (p < 0.001).
- 在牙周炎患者中,唾液uPA活性高出1.6倍 (p < 0.01).
- 升高的uPA和UPAR水平与牙周指数有很强的相关性,BMI和年龄的相关性较弱.
结论:
- uPA/uPAR系统的激活似乎在牙周疾病的发病过程中发挥了作用.
- uPA和UPAR显示出作为候选唾液生物标志物的潜力,用于诊断和理解牙周病原性.
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