抗生素耐药性的进化是由抗生素和抗生素生产中的典型有机污染物协同推动的废水
Sun Miao1, Yanyan Zhang1, Xin Yuan1
1State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
Journal of hazardous materials
|November 28, 2024
概括
抗生素生产中的有机污染物废水与抗生素协同作用,加速抗生素耐药性 (AR) 的演变. D-p-hydroxyphenylglycine与安培结合显著增加AR突变,突出了废水处理中的风险.
科学领域:
- 环境微生物学环境微生物学
- 抗微生物耐药性研究的研究.
- 废水处理技术 废水处理技术
背景情况:
- 抗生素生产废水 (APW) 存在由于剩余抗生素导致抗生素耐药性 (AR) 传播的风险.
- APW还含有有毒的有机污染物,可能与抗生素相互作用.
- 有机污染物在APW处理系统内AR发展中的作用在很大程度上是未知的.
研究的目的:
- 调查APW中的有机污染物对AR发展的贡献.
- 评估典型的APW有机污染物和安培 (AMP) 对大肠杆菌AR进化的协同效应.
主要方法:
- 野生型大肠杆菌菌株暴露在APW中发现的六种典型有机污染物中,单独和与AMP结合.
- 对AR突变频率和抗生素持久性的剂量时间响应分析.
- 现型和基因型分析以阐明协同作用的机制.
主要成果:
- 对有机化合物的个体暴露对AR进化产生了微不足道的影响.
- 有机污染物在与AMP结合时协同诱导AR突变和增加抗生素持久性.
- 在相关APW度下,D-p-hydroxyphenylglycine (DHPG) 与AMP显示出显著的协同效应,使突变频率增加到2928.9倍.
- 协同作用与增加的抗菌活性,氧化应激和增强的排泄表达有关.
结论:
- 在APW中的有机污染物显著提高了AR诱导的风险,当存在与抗生素.
- 废水处理策略必须考虑抗生素和有机污染物对AR的综合影响.
- DHPG是关键的有机污染物,加剧了APW环境中的AR风险.
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