热响应性水凝加载的高素通过类似收费的受体3激活诱导对Trichinella spiralis感染的炎症反应
Lingfeng Xie1, Ning Jiang1, Yi Liu1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, PR China.
概括
这项研究开发了一种充满高素 (Hyp) 的热反应性水凝,用于治疗Trichinella spiralis感染. 新的P ((NIPAM-co-AM) /Hyp水凝有效地激活了TLR3通路,减少了小鼠的寄生虫负载和炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 生物材料科学 生物材料科学
背景情况:
- 三螺旋菌感染对人类和动物构成致命的风险.
- 托尔类受体3 (TLR3) 激动剂在减少三菌感染方面表现有前途.
- 超素 (Hyp) 激活TLR3,但具有较差的溶解性和光毒性.
研究的目的:
- 开发一种热响应的水凝,以改善高素 (Hyp) 的传递和疗效.
- 通过激活TLR3.3,增强Hyp对T. spiralis的免疫治疗潜力.
主要方法:
- 一种热反应性水凝,P(NIPAM-co-AM),被合成并加载了高素 (Hyp).
- 特性包括较低的临界溶液温度 (LCST),生物相容性和通过TLR3信号传递的免疫调节活性.
- 评估了感染小鼠对T. spiralis的治疗疗效.
主要成果:
- 由于温度敏感性,P ((NIPAM-co-AM) /Hyp水凝证明了可控制的药物释放.
- 它有效地激活了TLR3通路,促进树突细胞成熟和促炎反应 (TNF-α,IFN-γ,IL-2,IL-12).
- 与Hyp和albendazole相比,肌肉幼虫负担显著减少 (高达64.30%) 和组织病理损伤被观察到.
结论:
- P ((NIPAM-co-AM) /Hyp水凝是一种有效的TLR3激动剂,用于治疗T. spiralis感染.
- 这种方法为寄生虫免疫疗法和疫苗开发提供了一个有希望的新策略.
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