童年不良经历与死亡率之间的关联:系统性审查和元分析
Lishuang Zheng1, Peiqi Liu2, Xin Li1
1School of Nursing, Jilin University, Changchun, China.
Psychiatry research
|November 28, 2024
概括
童年不良经历显著增加了整体,内部和外部原因死亡率的风险. 这一公共卫生问题需要紧急关注和有针对性的干预措施,以减轻长期健康后果.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 健康的社会决定因素
背景情况:
- 儿童不良经历 (ACE) 是一个重要的公共卫生问题.
- 关于ACE和死亡率的现有证据是不一致的.
- 需要全面了解ACE对死亡率的影响.
研究的目的:
- 系统地审查和元分析ACE和死亡率之间的关联.
- 探索ACE亚型对死亡结果的影响.
- 为了确定ACEs-死亡率关系中的潜在性别差异.
主要方法:
- 系统地搜索主要的科学数据库 (PubMed,科学网,EMBASE,CINAHL,科克兰图书馆).
- 包括49项研究,数据来自24,276,424名参与者.
- 进行元分析以计算死亡率结果的合并几率比率 (OR) 和置信区间 (CI).
主要成果:
- ACE与增加的整体死亡率 (OR,1.64),外部原因死亡率 (OR,1.91) 和内部原因死亡率 (OR,1.3) 有显著关联.
- 特定的ACE如虐待 (OR,1.95),家庭功能障碍 (OR,1.36),低社会经济地位 (OR,1.25) 和家庭外照顾 (OR,2.87) 显示死亡风险增加.
- 在死亡风险方面没有观察到统计学上显著的性别差异,低社会经济地位的差异较小.
结论:
- ACEs对各种原因的死亡率增加有相当大的风险.
- 公共卫生干预和政策对于解决ACE的长期影响至关重要.
- 进一步的研究可能会探索细微的性别特异性影响和干预策略.
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