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具有类似催化酶活性的添加碳点使MRI引导的增强光动力学治疗成为可能

Huihui Wang¹, Dongchuan Chu², Maolin Zhang²

¹Department of Radiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China; Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China.

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概括

新型碳点 (CD) 纳米酶增强瘤磁共振成像 (MRI) 和光动力学疗法 (PDT). 这些MPC-CD响应瘤微环境 (TME),提高了诊断和治疗的有效性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

瘤微环境 (TME) 带来了缺氧和酸度等挑战,阻碍了瘤磁共振成像 (MRI) 和光动力学疗法 (PDT).
碳点 (CD) 纳米酶提供了综合的诊断和治疗潜力,但开发具有卓越的MRI对比度和治疗效果的纳米酶仍然至关重要.

研究的目的:

合成新型碳点 (MPC-CDs) 来增强对TME敏感的MRI和协同作用的抗瘤作用.
评估MPC-CDs的诊断和治疗能力在体外和体内.

主要方法:

使用聚乙烯胺 (PEI),六基 (Ce6) 和合成新型碳点 (MPC-CDs).
评估光动力疗法 (PDT) 的效率,包括单次氧气产量.
通过在TME特定条件下 (酸度,H2O2) 测量r1和r2放松率来评估MRI能力.
在体外和体内研究以证实TME响应成像和抗瘤作用.

主要成果:

由于Ce6和的CAT类活性,MPC-CD显示出高单片氧产量 (1.52,高达H2O2的1.97) 由于Ce6和的CAT类活性.
在酸性和H2O2条件下,兴奋剂显著提高了MRI能力,在酸性和H2O2条件下,R1和R2放松率分别提高了7.8倍和4.6倍.
在体外和体内实验证实了MPC-CDs能够实现对TME敏感的MR成像和协同的抗瘤作用.

结论:

MPC-CDs是克服TME在瘤诊断和治疗方面的局限性的有希望的策略.
开发的纳米酶提供了增强的MRI对比度和强大的协同作用的抗瘤效应,提高整体治疗疗效.

关键词:

碳点纳米酶碳点纳米酶它具有类似catalase的活性.化物 e6 化物磁共振成像技术磁共振成像技术光动力学疗法是一种光动力学疗法.

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