饮食炎症潜力和与代谢 (功能障碍) 相关的脂肪性肝病及其并发症:综合性综述
Matin Sepehrinia1, Shaghayegh Khanmohammadi2, Nima Rezaei3
1Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Clinical nutrition ESPEN
|November 28, 2024
概括
通过饮食炎症指数 (DII) 和实证饮食炎症潜力 (EDIP) 测量的促炎症饮食与代谢 (功能障碍) 相关的脂肪性肝病 (MASLD) 的风险增加有关. 这个协会突出了饮食的重点.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢 (功能障碍) 相关的脂肪性肝病 (MASLD) 是与代谢综合征相关的日益严重的健康问题.
- 炎症是MASLD进展和肝损伤的关键驱动因素.
- 饮食是影响炎症和MASLD的可改变因素.
研究的目的:
- 审查和综合有关促进炎症饮食和MASLD之间的联系的证据.
- 检查饮食炎症指数 (DII) 和实证饮食炎症潜力 (EDIP) 在MASLD风险中的作用.
- 探索与晚期纤维化和肝细胞癌 (HCC) 的潜在联系.
主要方法:
- 对评估促炎症饮食 (DII,EDIP) 和MASLD的研究进行系统审查.
- 分析饮食炎症评分和MASLD发生之间的相关性.
- 评估有关BMI,纤维化和HCC风险的证据.
主要成果:
- 较高的DII/EDIP得分与增加的MASLD风险显著相关,特别是在男性中.
- 关于BMI影响和方法限制的不一致性.
- 初步数据表明,饮食炎症与晚期肝纤维化/HCC风险之间存在联系.
结论:
- 促炎性饮食通过胰岛素耐药性和肠道失调症等途径促进MASLD的发病.
- 需要使用可靠方法进行进一步的研究,以证实研究结果并指导干预措施.
- 饮食修改可能对MASLD管理至关重要.
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